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Article ID	#27700
Title	Increased hippocampal glucocorticoid receptor expression and reduced anxiety-like behavior following Tuina in a rat model with allergic airway inflammation
URL	https://pubmed.ncbi.nlm.nih.gov/37294215/
Journal	J Manipulative Physiol Ther. 2022 Oct;45(8):586-594
Author(s)	Liu Y Cao L Liu J Zhang Z Fan P Zhu Y Zhang S Gu Y Li Q Xiong Y
Subject(s)	Anxiety / therapy Glucocorticoids Hippocampus Massage / methods Medicine, Chinese Traditional Rats Rats, Sprague-Dawley Receptors, Glucocorticoid
Peer Review	Yes
Publication Type	Article
Abstract/Notes	Objective: This study aimed to explore the influence mechanism of Tuina on anxiety-like behavior in immature rats with allergic airway inflammation (AAI). Methods: A total of 27 Sprague-Dawley male rats (aged ∼5 weeks) were divided randomly into control, AAI, and AAI with Tuina groups (9 rats per group). The anxiety-like behavior was assessed by an open field test and elevated plus-maze test. Allergic airway inflammation was assessed based on the pathological score of the lung, plasma ovalbumin-specific immunoglobulin E, interleukin 4, interleukin 5, and tumor necrosis factor-alpha levels. Glucocorticoid receptor (GR) messenger RNA and protein expression in the hippocampus and lung were detected by polymerase chain reaction and immunohistochemistry, respectively. Meanwhile, corticotropin-releasing hormone (CRH) messenger RNA in the hypothalamus, the plasma levels of adrenocorticotropic hormone and corticosterone were also determined respectively by polymerase chain reaction and enzyme-linked immunosorbent assay for hypothalamic-pituitary-adrenal axis (HPA) function. Results: The AAI group had obvious anxiety-like behavior and hyperactive HPA axis, along with decreased GR expression in the hippocampus and lung. Following Tuina, AAI and the anxiety-like behavior were efficiently reduced, and the hyperactivity of HPA axis was efficiently inhibited, along with enhanced GR expression in the hippocampus and lung. Conclusion: Glucocorticoid receptor expression in the hippocampus and lung was enhanced, and anxiety-like behavior was reduced following Tuina in rats with AAI. Author keywords: Asthma; Anxiety; Receptors, Glucocorticoid; Massage; Musculoskeletal Manipulations This abstract is reproduced with the permission of the publisher; full text is available by subscription. Click on the above link and select a publisher from PubMed's LinkOut feature.

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