Abstract: The purpose of this literature review is to report the Top Five papers forming the current evidence on chiropractic care and immune function. The paper covers five significant studies, include meta-analyses and systemic reviews, in order to create context and background for the case reports included in this issue of the Journal.
Despite strong debate, it is clear from the included reviews and meta-analyses that evidence for SMT modulating biochemical markers of immune function does indeed exist. This literature review found evidence for improvements in inflammatory cytokines, specifically IL-beta and TNF-alpha, interleukin (IL) 1β and the neurotransmitter Substance P. Other included evidence shows indications that SMT may impact neurotensin, oxytocin and immunological biomarkers. Further research will be beneficial in terms of raising the quality of evidence, examining asymptomatic and
symptomatic patients, and defining the mechanisms behind the observed improvements. However, the current evidence provides a strong starting point for future efforts
Author keywords: Chiropractic - Subluxation - Immunity
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