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Article ID	#25247
Title	Manual mobilization of subcutaneous fibrosis in mice
URL	https://www.ncbi.nlm.nih.gov/pubmed/29933891
Journal	J Manipulative Physiol Ther. 2018 Jun;41(5):359-362
Author(s)	Altomare M Monte-Alto-Costa A
Subject(s)	Affiliation / Rio de Janeiro State University. Tissue Repair Laboratory Affiliation(G) / Brazil / Rio de Janeiro / Rio de Janeiro Extracellular Matrix Fibrosis Mice Mobilization
Peer Review	Yes
Publication Type	Article
Abstract/Notes	Objective: The aim of this study was to induce the remodeling of subcutaneous fibrosis in mice by the manual mobilization of skin and subcutaneous tissue. Methods: Seven days after the induction of subcutaneous fibrosis, mice were divided into 3 groups: control, stretch, and manual mobilization. Stretch was achieved by elongating the trunk, and manual mobilization was achieved by using the indicator fingertip of both hands, side by side, touching the back and performing a brief stretch. Stretch or manual mobilization was performed once a day for 7 days. Results: Fibrosis was present in the subcutaneous tissue of control animals, whereas brief stretch and manual mobilization were found to reduce fibrosis. Conclusions: Mechanical stimulation through manual mobilization, or brief stretching, reduced subcutaneous fibrosis after tissue injury. Author keywords: Fibrosis, Extracellular Matrix, Musculoskeletal Manipulations, Mice Author affiliations: Tissue Repair Laboratory, Rio de Janeiro State University, Rio de Janeiro, Brazil This abstract is reproduced with the permission of the publisher; full text is available by subscription. Click on the above link and select a publisher from PubMed's LinkOut feature.