Background: Despite enormous effort spent in determining a cause for infant colic, the source of the problem still eludes researchers.
Objective: To review the published evidence to establish whether infant colic is due to an allergic reaction to cow's milk.
Method: A literature search was completed using Medline, Cochrane Clinical Review and a hand search from 1980 to March 2013. Publications were included if they were systematic reviews, RCTs with a control group, or specifically related to dietary interventions.
Conclusion: There is no clear evidence that infant colic is a form of cow's milk protein allergy (CMPA). Research trials have been contaminated with a subgroup of infants who have been diagnosed with colic who actually have CMPA. Future studies need to subgroup the irritable infant to better understand the etiology of colic.
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