| OBJECTIVE: To discuss a case of unifocal Langerhans cell histiocytosis (eosinophilic granuloma) presenting as an aggressive osseous destructive process. CLINICAL FEATURES: A 6-year-old girl had thigh pain of insidious onset that would wake her at night. Orthopedic testing reproduced local pain, and imaging revealed an osteolytic process in the femoral diaphysis with laminated periosteal reaction. INTERVENTION AND OUTCOME: The patient was referred for further evaluation; unifocal Langerhans cell histiocytosis was found at biopsy and spontaneous healing subsequently reported. CONCLUSIONS: Unifocal Langerhans cell histiocytosis may present with deceptive clinical and imaging findings, of which clinicians should be aware. Click on the above link for the PubMed record for this article; full text by subscription. The abstract is reproduced here with the permission of the publisher.
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